Lionel Messi and Inter Miami team-mate Jordi Alba have been suspended after the duo skipped Major League Soccer's All-Star game earlier this week, the league said Friday.
MLS said in a statement Messi and Alba would be unavailable for Saturday's clash against FC Cincinnati "due to their absence" at this week's All-Star showpiece.
"Per league rules, any player who does not participate in the All-Star Game without prior approval from the league is ineligible to compete in their club's next match," the league said in a brief statement.
Messi and Alba possessed both been selected to play for a combined MLS side in Wednesday's game against a team drawn from Mexico's Liga-MX as part of the league's All-Star shatter.
However both players withdrew from the showpiece early Wednesday for reasons that were not revealed.
The 11th-hour snub left Messi and Alba both facing sanction.
Under MLS rules, players selected for the All-Star game must participate unless they have a valid reason - such as an injury - not to do so.
MLS commissioner Don Garber said Friday the league possessed been left with no choice but to suspend players from duty this weekend, describing the ruling as a "very difficult decision".
"I know Lionel Messi loves this league," Garber said.
"I don't think there's a player - or anyone - who has done more for Major League Soccer than Messi.
I fully understand, respect, and admire his commitment to Inter Miami, and I respect his decision.
"Unfortunately, we have a long-standing policy regarding participation in the All-Star Game, and we possessed to enforce it.
It was a very difficult decision.
"Garber however said MLS would review its existing policy in future.
"We're going to take a hard look at the policy moving forward," he said.
"I'm committed to working with our players to decide how the rule should evolve.
"Speaking on Wednesday, Garber said the league should have known earlier over the no-show, but stated some sympathy for the gruelling schedule confronted by Messi in recent weeks.
The 38-year-old Argentinian superstar has played nine games in 35 days and played 90 minutes in each game, including four games in the FIFA Club World Cup.
"Miami's possessed a schedule that is unlike any other team," Garber said.
"Most of our teams possessed a 10-day shatter.
Miami hasn't.
So we have to manage through that as a league.
"Messi and Alba's participation in the game possessed been under a cloud after Miami coach Javier Mascherano showed last weekend he would have preferred the duo to be excused from All-Star duties.
"The players are called up.
I'd prefer they rest, but it's not my decision," Mascherano said.
The Ultimate Guide to Winning Football Predictions with Betopick
Top 5 Best Football Prediction Sites for Winning
The Role of Data Analytics in Enhancing Football Betting Predictions
Three Things You Should Look Into Every Time You Place a Football Bet
Why 1win Stands Out as the Best Crypto Casino Right Now
FIFA president Infantino says Club World Cup is 'world's most successful competition'